For some time we’ve been pointing out the massive pile of evidence that THC and other cannabinoids have potential as anticancer drugs. A new study out of Thailand demonstrates that THC can fight cholangiocarcinoma – cancer of the bile duct. This is a rare but deadly form of cancer, with only 30 percent of patients still alive after five years, according to the  Cholangiocarcinoma Foundation. Based on these new lab results, the Thai researchers conclude, “THC is potentially used to retard cholangiocarcinoma cell growth and metastasis.”

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One thing that drives me crazy is the tendency of the media and others to refer to THC as “the active ingredient” in marijuana. While THC is indeed responsible for marijuana’s “high,” it is one of about 80 unique compounds, called cannabinoids, that are not seen in any other plant. Many of these have interesting, potentially significant, medical applications, and are not psychoactive.

Anyone who wants to learn about these other cannabinoids should check out this recent review published in the journal Trends in Pharmacological Sciences. [Read more →]

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The surprising finding that THC might help at least a small percentage of schizophrenia patients for whom conventional treatments have failed was reported in the June issue of the Journal of Clinical Psychopharmacology. 

This is surprising because, as the British government’s Advisory Council on the Misuse of Drugs reported last year, “there is clear evidence that the use of cannabis may worsen the symptoms of schizophrenia and lead to relapse.” [Read more →]

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MPP’s Bruce Mirken will appear on CNN’s “Anderson Cooper 360″ tonight to add a little rationality to the latest pronouncement regarding rising THC levels in marijuana from the National Institute on Drug Abuse-funded Marijuana Potency Project.

Drug warriors love to exaggerate small increases in marijuana potency over time and make vague proclamations linking those increases to increases in marijuana’s potential danger, even though no credible research supports such a connection. Of course, if they were truly concerned about the potential danger of higher potency marijuana, then they should favor regulating the drug and requiring manufacturers to label the product’s potency, just as we do with alcohol.

The show is scheduled to air tonight at 10 p.m. EST, but the hysteria surrounding one of the drug warriors’ favorite imaginary fears is sure to last much longer.

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The evidence continues to mount that cannabinoids — the unique, active components in marijuana — fight cancer. The latest such study , just published in the Journal of Clinical Investigation, shows that THC can kill glioma cells through a process known as autophagy. Gioma is a particularly deadly form of brain cancer that afflicts, among others, Sen. Edward M. Kennedy (D-Mass.).

The good news is that this study got a decent amount of media attention. The bad news is that much of the coverage lacked context or presented information in a confusing or misleading way. Case in point: the April 1 story from the Reuters wire service.

Reuters reporter Michael Kahn presents the finding as if it were something brand new, failing to note the extensive evidence accumulated since the 1970s that cannabinoids fight various types of tumors. It reports that “studies have suggested” that marijuana may cause cancer, omitting the fact that the largest, most well-controlled studies have found precisely the opposite.

And finally, in a warning of possible risks of cannabinoid drugs, the article hopelessly jumbles cannabinoids — drugs like THC and its plant and synthetic cousins — with drugs designed to block the CB1 receptor through which these substances operate, mistakenly referring to these CB1-blocking drugs as cannabinoids. In fact, they’re more like anti-cannabinoids, and if anything the harmful effects of these CB1 blockers (increased rates of depression and anxiety, for example) reaffirm that cannabinoids often have good and helpful effects.

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