One thing that drives me crazy is the tendency of the media and others to refer to THC as “the active ingredient” in marijuana. While THC is indeed responsible for marijuana’s “high,” it is one of about 80 unique compounds, called cannabinoids, that are not seen in any other plant. Many of these have interesting, potentially significant, medical applications, and are not psychoactive.

Anyone who wants to learn about these other cannabinoids should check out this recent review published in the journal Trends in Pharmacological Sciences. [Read more →]

The International Association for Cannabis as Medicine just concluded its 5^th Conference on Cannabinoids in Medicine in Cologne, Germany. The conference included significant new evidence that marijuana is a safe, effective medicine for certain conditions, some of which can be found in the conference abstracts, now available online.

Canadian researcher Mark Ware presented results of a yearlong safety study known as the COMPASS study, which compared 215 patients who used marijuana to manage chronic pain with comparable control patients who did not use marijuana. Ware and colleagues report “no difference in serious adverse events” between the two groups, concluding, “Cannabis use for chronic pain over one year is not associated with major changes in lung, endocrine, cognitive function or serious adverse events.” [Read more →]

At least some in the international news media have belatedly discovered a study casting doubt on the purported link between marijuana use and schizophrenia. I say “belatedly” because the study was published online back in June, although the print version came out this month.

A group of British researchers examined a rather basic notion: If marijuana use  causes schizophrenia, then a major increase in marijuana use should lead to an increase in schizophrenia diagnoses in the following years. In an enormous sample of some 600,000 Britons, no such thing occurred – indeed, a spike in marijuana use beginning in the mid-1970s was followed by rates of schizophrenia that either remained stable or declined.

Of course this is not the first time that a lack of connection between marijuana use rates and schizophrenia incidence has been noted in the scientific literature. For example, a 2006 review in the Canadian Journal of Psychiatry noted that “the treated incidence of schizophrenia did not obviously increase during the 1970s and 1980s when there were substantial increases in cannabis use among young adults in Australia and North America.” (Alas, that rather important discussion isn’t mentioned in the summary linked above, which is all you can get for free).

Overall, the evidence strongly suggests that marijuana may worsen or trigger schizophrenia in a few individuals with a pre-existing vulnerability, but that it is not a significant cause of mental illness in healthy people. That rather nuanced reality tends to be a bit too complicated for many in the media.

We’ve all heard the claims before – from federal officials, police groups opposing state medical marijuana bills, etc. – that there is no evidence that marijuana is a legitimate medicine. Readers of this blog know that’s nonsense, but there’s been a need for an article in the peer-reviewed scientific literature that lays out the scientific case in a clear, tightly-focused way.

Recently, a group of scientists published a review article in the Journal of Opioid Management that does just that. The article, “Medicinal Use of Cannabis in the United States: Historical Perspectives, Current Trends, and Future Directions,” is one every medical marijuana activist should keep handy. [Read more →]

A study just published online by the journal Neurotoxicology and Teratology suggests that marijuana may protect the brain from some of the damage caused by binge drinking.

The study, by researchers at the University of California San Diego, used a type of high-tech scan called diffusion tensor imaging to compare microscopic changes in brain white matter. The subjects were students aged 16-to-19, divided into three groups: binge drinkers (defined as having five or more drinks at one sitting for boys or four or more for girls), binge drinkers who also smoked marijuana, and a control group who had very little or no experience with either alcohol or drugs.

As expected, the binge-drinking-only group showed evidence of white matter damage in eight regions examined, as demonstrated by lower fractional anisotropy (FA) scores. But in a finding the researchers described as “unexpected,” the binge-drinking/marijuana group had lower FA scores than the controls in only three of the eight regions, and in seven regions the binge-drinking/marijuana group had higher scores – indicating less damage – than the binge drinkers who didn’t use marijuana (unfortunately, not all of these stats are in the summary linked above; access to the full article requires payment). [Read more →]

MPP’s director of state campaigns, Steve Fox, is the co-author of a new book entitled, Marijuana is Safer: So why are we driving people to drink? The purpose of this book is to educate Americans about the relative harms of marijuana and alcohol, and to force them to consider why we punish adults who use the less harmful substance.  The critically acclaimed book also provides supporters of marijuana policy reform with the information and talking points necessary to spread the “marijuana is safer” message to friends and family.

To raise awareness about the book, the authors are coordinating a “Book Bomb” that will take place tomorrow, August 20.  The goal is to have hundreds of people order the book from Amazon.com on the same day so that it reaches #1 on the online bookseller’s rankings.  As far as we know, no book advocating for marijuana policy reform has reached that milestone.  To learn more about the book and to sign up for the Book Bomb, visit http://www.marijuanabookbomb.com If you sign up, you will get an email tomorrow reminding you about the Bomb.

Thanks in advance for participating!  And please share this blog post with any friends who might be interested.

Among the more interesting pieces of news that came out while I was on vacation the first half of August was a new study in the journal Cancer Prevention Research, which found that marijuana smokers have a lower risk of head and neck cancers than people who don’t smoke marijuana. Alas, this important research has been largely ignored by the news media.

While this type of study cannot conclusively prove cause and effect, the combination of this new study and existing research — which for decades has shown that cannabinoids are fairly potent anticancer drugs — raises a significant possibility that marijuana use is in fact protective against certain types of cancer. [Read more →]

To their great credit, the editors at Forbes.com offered us the opportunity to respond today to last week’s absurd column by Rachel Ehrenfeld. Enjoy.