The journal Clinical EEG and Neuroscience has just published a review of the data on the effects of substance use on the developing brains of adolescents. The unmistakable conclusion: While heavy substance use of any kind is a really bad idea for teens, the damaging effects of alcohol are clearly worse than marijuana. The researchers write:

Abnormalities have been seen in brain structure volume, white matter quality, and activation to cognitive tasks, even in youth with as little as 1-2 years of heavy drinking and consumption levels of 20 drinks per month, especially if >4-5 drinks are consumed on a single occasion. Heavy marijuana users show some subtle anomalies too, but generally not the same degree of divergence from demographically similar non-using adolescents.

Strikingly, in a couple of studies, the damaging effects of binge drinking were less if the drinker also used marijuana, suggesting — though not proving — a possible protective effect in some circumstances. That’s actually no shock, as the U.S. government holds a patent  on cannabinoids — marijuana’s unique, active components — as neuroprotectants (substances that protect nerve and brain cells from damage).

People suffering from Parkinson’s disease have a high rate of psychosis, which may be induced or worsened by drugs used to treat the illness. A recently published study in the Journal of Psychopharmacology suggests that a marijuana component called cannabidiol (CBD) may be a helpful treatment for this condition.

This was a small, uncontrolled pilot study, but CBD produced rapid and fairly dramatic reductions in psychotic symptoms. And the growing body of evidence regarding CBD’s anti-psychotic properties has important implications beyond Parkinson’s patients. For example, there is some evidence that THC can worsen psychotic symptoms, but at least one study has implied that CBD, if present in sufficient quantities, can counter this effect. 

It’s been known for a while that some cannabinoids, the active components in marijuana, have antibacterial properties (one of many useful facts you won’t find on ONDCP’s Web site). Now, as noted by stories in the New York Times and Web MD, five cannabinoids, including THC, have been shown to be active against a particularly worrisome form of staph infection that’s resistant to conventional antibiotics. It took these major media outlets a while to catch up with the study, published August 6 in the Journal of Natural Products, but at least they covered it. 

A new article in the European Journal of Cancer Care answers medical marijuana opponents who claim that cancer patients don’t need marijuana to relieve the nausea and vomiting from chemotherapy. Opponents claim that while studies in the past showed THC to be roughly comparable to other anti-nausea drugs, it wasn’t substantially better. Since those studies, they argue, better anti-nausea drugs have come into use, making medical marijuana irrelevant. In any case, they add, THC is available in pill form as Marinol. [Read more →]

Could marijuana be helpful for attention deficit hyperactivity disorder (ADHD)? The possibility is raised by a newly published case report in Cannabinoids, the journal of the International Association for Cannabis as Medicine. Doctors from the Heidelberg University Medical Center in Heidelberg, Germany, report on an adult ADHD sufferer who exhibited classic ADHD behavior — pushy, impatient, having trouble focusing or responding to questions appropriately — and who had not been helped by Ritalin, a standard ADHD treatment, but whose symptoms essentially disappeared after smoking marijuana. The authors also discuss animal research that suggests cannabinoids may be effective against ADHD, as well as a human study suggesting that moderate marijuana use may have helped ADHD patients with cocaine dependence stay in treatment.

Some studies have found an association between marijuana use and ADHD symptoms, often drawing the inference that marijuana is worsening ADHD, or that ADHD sufferers are at risk for “drug abuse.” But what if they’re self-medicating and — in at least some cases — actually helping reduce their symptoms?