Category — Research

David Nutt, removed as chair of the British government’s Advisory Council on the Misuse of Drugs for daring to speak the unwanted truth that marijuana is safer than alcohol, is speaking out again, this time in the pages of The Lancet, one of the world’s top medical journals. Unfortunately, you can read only the first few lines of Nutt’s column unless you pay for full access (correction: you have to register but don’t have to pay — thanks to Just Legalize It for pointing this out), but he makes a critical point that many politicians surely won’t like: “The control of cannabis use through regulation rather than criminalisation has proved safe and effective in the Netherlands, and was indeed suggested in The Lancet as far back as 1963.”

Maybe someday governments will base policy on facts and data. It sure would be nice.

For some time we’ve been pointing out the massive pile of evidence that THC and other cannabinoids have potential as anticancer drugs. A new study out of Thailand demonstrates that THC can fight cholangiocarcinoma – cancer of the bile duct. This is a rare but deadly form of cancer, with only 30 percent of patients still alive after five years, according to the  Cholangiocarcinoma Foundation. Based on these new lab results, the Thai researchers conclude, “THC is potentially used to retard cholangiocarcinoma cell growth and metastasis.”

There has long been reason to think that marijuana may be helpful to some patients with bipolar disorder, as certain cannabinoids have been shown in lab and animal studies to have effects that ought to be beneficial. Now, a new study from the University of Oslo finds that marijuana use is associated with better neurocognitive functioning in bipolar patients. In various tests of memory, learning, etc., bipolar patients who used marijuana did better than those who didn’t use it – the exact opposite of what the researchers found in patients with schizophrenia, a condition marijuana can sometimes worsen. “The findings,” the scientists write, “suggest that cannabis use may be related to improved neurocognition in bipolar disorder.”

That alcohol causes cancer isn’t really news, but how it does so hasn’t been fully understood. A new study, published in the journal Alcoholism: Clinical and Experimental Research, adds an important new piece of information. Alcohol, it turns out, stimulates a type of cell transformation that turns cancer cells more aggressive and thus more likely to spread throughout the body.

As we’ve noted before, research shows that cannabinoids (marijuana’s unique, active components) interfere with tumor growth and may actually prevent cancer.

Two members of Britain’s Advisory Council on the Misuse of Drugs have resigned in protest after the group’s chairman, Professor David Nutt, was fired last week for criticizing the UK government’s decision to strengthen penalties for marijuana offenses. Chemist Les King and pharmacist Marion Walker said that the government wrongly dismissed Nutt and violated his freedom of expression. [Read more →]

Yesterday I posted a brief summary of a new study of vaporization of marijuana as an alternative to smoking. Since that original post, I’ve spoken to a couple of researchers about this study, and they raised a few points that seem worth sharing:

First, for reasons that aren’t clear, before performing the tests of smoking and vaporization, the researchers put the marijuana through a drying procedure that ordinary marijuana consumers don’t do. This might have eliminated some plant compounds, such as terpenoids, that are actually of interest.

A second possible flaw is that the researchers considered all “byproducts” – defined as substances other than cannabinoids –  together. They didn’t analyze precisely what they were, lumping bad stuff like the toxic combustion products contained in smoke with potentially beneficial plant compounds like those terpenoids mentioned above. That puts the finding that fewer byproducts were produced at 230 degrees Celsius than were produced at lower temperatures in a somewhat different perspective: We don’t know if the same byproducts were produced at 230 degrees as were produced at lower temperatures – and what’s in that mixture could be just as important as how much of it there is.

Professor David Nutt, chairman of Great Britain’s advisory council on the misuse of drugs, was forced to resign today after he criticized the British government’s decision to toughen penalties for marijuana possession. [Read more →]

Opponents of medical marijuana love to condemn smoking, but a new study adds more data to the growing pile of research confirming that vaporization provides the benefits of inhalation without the unwanted combustion products in smoke.  In a study comparing vaporization to smoking in the journal Inhalation Toxicology, researchers from Leiden University report, “Based on the results, we can conclude that with the use of the vaporizer a much ‘cleaner’ and therefore a more healthy cannabis vapor can be produced for the medicinal use of C. sativa, in comparison to the administration of THC via cigarettes.”

The article also provides some new practical information on vaporization, suggesting that a temperature of 230 degrees Celsius is ideal, and that using smaller amounts of marijuana in the vaporizer produces more vapor, but does not extract THC more efficiently, so there is no apparent gain in using an amount less than about half a gram at a time.