Category — Research

That alcohol causes cancer isn’t really news, but how it does so hasn’t been fully understood. A new study, published in the journal Alcoholism: Clinical and Experimental Research, adds an important new piece of information. Alcohol, it turns out, stimulates a type of cell transformation that turns cancer cells more aggressive and thus more likely to spread throughout the body.

As we’ve noted before, research shows that cannabinoids (marijuana’s unique, active components) interfere with tumor growth and may actually prevent cancer.

Two members of Britain’s Advisory Council on the Misuse of Drugs have resigned in protest after the group’s chairman, Professor David Nutt, was fired last week for criticizing the UK government’s decision to strengthen penalties for marijuana offenses. Chemist Les King and pharmacist Marion Walker said that the government wrongly dismissed Nutt and violated his freedom of expression. [Read more →]

Yesterday I posted a brief summary of a new study of vaporization of marijuana as an alternative to smoking. Since that original post, I’ve spoken to a couple of researchers about this study, and they raised a few points that seem worth sharing:

First, for reasons that aren’t clear, before performing the tests of smoking and vaporization, the researchers put the marijuana through a drying procedure that ordinary marijuana consumers don’t do. This might have eliminated some plant compounds, such as terpenoids, that are actually of interest.

A second possible flaw is that the researchers considered all “byproducts” – defined as substances other than cannabinoids –  together. They didn’t analyze precisely what they were, lumping bad stuff like the toxic combustion products contained in smoke with potentially beneficial plant compounds like those terpenoids mentioned above. That puts the finding that fewer byproducts were produced at 230 degrees Celsius than were produced at lower temperatures in a somewhat different perspective: We don’t know if the same byproducts were produced at 230 degrees as were produced at lower temperatures – and what’s in that mixture could be just as important as how much of it there is.

Professor David Nutt, chairman of Great Britain’s advisory council on the misuse of drugs, was forced to resign today after he criticized the British government’s decision to toughen penalties for marijuana possession. [Read more →]

Opponents of medical marijuana love to condemn smoking, but a new study adds more data to the growing pile of research confirming that vaporization provides the benefits of inhalation without the unwanted combustion products in smoke.  In a study comparing vaporization to smoking in the journal Inhalation Toxicology, researchers from Leiden University report, “Based on the results, we can conclude that with the use of the vaporizer a much ‘cleaner’ and therefore a more healthy cannabis vapor can be produced for the medicinal use of C. sativa, in comparison to the administration of THC via cigarettes.”

The article also provides some new practical information on vaporization, suggesting that a temperature of 230 degrees Celsius is ideal, and that using smaller amounts of marijuana in the vaporizer produces more vapor, but does not extract THC more efficiently, so there is no apparent gain in using an amount less than about half a gram at a time.

Monday’s Gallup poll showing that a record 44% of Americans favor making marijuana legal has brought increased attention to the need for an open, national debate on marijuana policy.

The fact that 44% percent of people favor taxing and regulating marijuana is even more impressive because—in stark contrast to many other public policy issues—for once, a substantial number of Americans actually view an issue favorably.

After all, Americans are a finicky bunch. We don’t like much these days, and in 2009 it’s impressive for anything to get 44% approval ratings. In fact, according to the latest numbers from a variety of polling sources, the idea of taxing and regulating marijuana enjoys higher support among the American public than the wars in Afghanistan and Iraq, the top Democrat and top Republican in the House of Representatives, and—perhaps not surprisingly—Congress itself.

Take a look at these figures:

Based on these numbers, as well as the growing mainstream media coverage of marijuana issues, there is no longer any doubt that Americans see marijuana policy reform as a legitimate mainstream issue worthy of national debate. Let’s keep talking!

One thing that drives me crazy is the tendency of the media and others to refer to THC as “the active ingredient” in marijuana. While THC is indeed responsible for marijuana’s “high,” it is one of about 80 unique compounds, called cannabinoids, that are not seen in any other plant. Many of these have interesting, potentially significant, medical applications, and are not psychoactive.

Anyone who wants to learn about these other cannabinoids should check out this recent review published in the journal Trends in Pharmacological Sciences. [Read more →]

The International Association for Cannabis as Medicine just concluded its 5^th Conference on Cannabinoids in Medicine in Cologne, Germany. The conference included significant new evidence that marijuana is a safe, effective medicine for certain conditions, some of which can be found in the conference abstracts, now available online.

Canadian researcher Mark Ware presented results of a yearlong safety study known as the COMPASS study, which compared 215 patients who used marijuana to manage chronic pain with comparable control patients who did not use marijuana. Ware and colleagues report “no difference in serious adverse events” between the two groups, concluding, “Cannabis use for chronic pain over one year is not associated with major changes in lung, endocrine, cognitive function or serious adverse events.” [Read more →]